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Bharat B. Tripathi, Ph.D.

School of Mathematical and Statistical Sciences

Modeling and Simulation of Shear Shock Waves in context of Traumatic Brain Injury

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Figure 1: Human head

Recent observation of shear shock waves in brain has created the need for its theoretical modeling and numerical simulation to better understand the possiblity of formation of such waves, and thus its physiological effects, in the event of an impact.

We have developed the state of the art theoretical model and its numerical simulation solver describing the propagation of linearly polarized shear shock waves in relaxing soft solids. This model and simulation has been thoroughly validated using direct measurements of displacements in soft solids using ultrafast ultrasound imaging. Figure 1 shows the saggital and axial section of a human head used for constructing a human head phantom shown in Figure 2(a), attached to an electromechanical shaker. A benign impact (with acceleration 19\(g\)) at the surface spontaneously generates a very high local acceleration (266\(g\)) deep inside the brain-mimicking gelatin phantom filled inside the skull phantom due to formation of shear shocks. Measurements of the average velocity in the gelatin and the simulation shows a convincing match as evident from Figure 2(b,c) while demonstrating the formation and focusing of shear shock waves caused inside the skull. The time plots of velocity (Figure 2(d,e,f)), acceleration (Figure 2(g,h,i)), and strain-rate (Figure 2(j,k,l)) at three different locations show an excellent agreement between experimental measurements and simulations. To highlight the importance of nonlinear simulations a contrast with a linear simulation is shown in Video 1, notice the faster speed of propagation and sharp focusing of shock waves in the nonlinear waves which is absent in the linear case.

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Figure 2: Human head phantom experiment setup (a), average velocity in experiments (b) and simulation (c). Comparison between experimental and simulation of particle velocity, acceleration, strain-rate at three different locations is shown in second, third and fourth rows, respectively.
Video 1: Linear and nonlinear simulation in brain.
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Figure 3: Maximum acceleration (\(g\)) in the three regimes 25 Hz, 75 Hz, 200 Hz shown in subplots a,b,c, respectively. Subplots d,e,f, shows the difference between acceleration, strain and strain-rate in the linear and nonlinear simulation.

Ongoing Work:

  1. 3D system of equations describing the propagation of shear shock waves in the brain with the correct modeling of power-law attenuation and dispersion.
  2. Discontinuous Galerkin method-based numerical solver for this 3D system of equations.
  3. Custom neural networks for nonlinear viscoelastic characterization of soft tissues.
  4. Uncertainty quantification in the model response and model calibration.

More Projects Coming Soon